A significant and clinically relevant improvement in these parameters would provide a solid rationale for performing a subsequent trial testing histological improvement.
The methodology for doing systematic reviews is well developed nowadays and well described for instance in the Cochrane handbook for reviewers, but a well founded methodology and rationale for performing a systematic review of reviews is currently lacking, especially with regard to the ways of synthesizing data.
The rationale for performing a clinical genetics consultation for a patient with an ASD is clear to the clinical geneticist.
The rationale for performing a pathway-based analysis in a GWAS lies in the assumption that several genes, each modestly associated with the disease, may interact synergistically to confer susceptibility.
The conventional rationale for performing a vitrectomy is to relieve vitreoretinal traction and obtain a temporary endotamponade effect in order to seal retinal breaks and to reposition the detached retina against the retinal pigment epithelium.
If these conditions are not met, there is no clear scientific rationale for performing a DI study.
The positive, although less so, associated treatment effect observed after controlling for illness severity provides further rationale for performing a randomized controlled trial in the pediatric Turkish TAMOF network.
The rationale for performing a pooled analysis was that it provided greater statistical power for detecting significant differences in these end points between memantine and placebo, providing confirmation of the results presented in the original reports.
However, the rationale for performing an OGTT in all patients with FPG < 110 mg/dL (6.1 mmol/L) was not substantiated and such practice may also entail testing a large number of patients, which may not be feasible.
