The following observation made by one panellist, a RM/funder, serves to illustrate the potential for variation in the way members of the public can be involved: …hard to imagine a rationale for no involvement, but it will vary from project to project.
[RM, Round 2] …hard to imagine a rationale for no involvement, but it will vary from project to project.
This offers a rationale for investigating the involvement of different subtypes of tubulin in resistance to AVE9633/DM4, and for studying the benefit of AVE9633 in combination with the conventional anthracycline AML regimens, resistance to which is related to the expression of ABC proteins.
In addition to p53 control, the positive regulation of GLI1 activity by the major human oncogenes (RAS, AKT; Stecca et al, 2007), and its negative regulation by the tumour suppressor PTEN (Stecca et al, 2007), highlights the exquisite regulation of GLI1 activity and provides a rationale for its widespread involvement in human cancer.
A major concern of the Russians is that American accusations of chemical weapons use will become a rationale for greater American and Western involvement in the crisis, including possible military action.
Given the severity of seizures and the association with acute neurological deficit, there is a rationale for the diagnosis of brain involvement in asymptomatic infants and children.
Is there a rationale for public investment and for the involvement of international financing partners?
A rationale for this may be the greater involvement of service funders and providers in the consultation.
The increase in postdisaster disability-related outcomes has provided a rationale for the increased role of the disability and rehabilitation sector's involvement in emergency response, including physical therapists.
Credibility as a rationale for escalation has been a matter of controversy since the Vietnam War, when deeper involvement was justified in part to show that U.S. commitments could be trusted.
The presence of ANCA suggests an involvement of B cells in disease pathogenesis and may provide a rationale for the use of a B cell-depleting therapeutic strategy.
