First, there is a strong rationale for identifying HIV-1 peptides presented by distinct MHC class I molecules that may be recognised by T cells and/or NK cells in vivo.
A significant rationale for identifying RCC-associated hypermethylated TSGs is their potential role as biomarkers to identify high-risk individuals and presymptomatic tumours by analysis of urine samples (Battagli et al, 2003; Hoque et al, 2004).
The possibility of preserving β-cell function provides an alternative rationale for identifying T1D at an earlier stage of its development.
Substantial epidemiological evidence has provided the rationale for identifying prolonged workplace sitting time as an emerging public health concern.
In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
For example, the rationale for identifying peak AA, as seen in Table 1, was: Altenusin C15H14O6 was from Alternaria and thus taxonomically unlikely.
The rationale for identifying biomarkers during pathological states, such as severe sepsis, is to improve clinical prognostication and stratify therapeutic interventions for optimal recovery.
Rather, they may provide the rationale for identifying other druggable genes whose loss of function is selectively toxic for cancer cells.
