On the micro scale, it can produce exchanges that proceed by perfectly rational sequence to an email reading: "Dad, you are a very naughty girl".
This simple, yet rational sequence modification was made to change the amphiphilic pattern and secondary structural content of the parent peptide, thereby modulating its self-assembly process.
As a consequence, only rational sequencing, which consists in choosing an agent that is not expected to have cross-resistance with previous therapy, can be currently advised.
However, since individual mutations do not tend to confer pan-antagonist resistance, the development of real-time strategies to monitor for AR mutation emergence could guide rational sequencing of AR pathway inhibitors.
Recently, Du [7] and Lin and Du [3] defined the concepts of sizing-up function and -bounded quasiordered set (see Definitions 1.1 and 1.3 below) to describe a rational condition for a nondecreasing sequence on a quasiordered set to have an upper bound.
By analysing the chronological order and focuses of the documents, we aimed to establish whether there was a high degree of overall coherence and a clear time sequence, implying a rational approach to strategic planning and a desire for effective organisational guidelines.
We then adopted the sequence of a rational planning framework, first defining the vision statement and planned strategic position, then selecting the service portfolio and resource allocation, and ending with organisational development and stakeholder accountability [ 7, 20, 21] in order to assess the degree of logical correlation between strategic documents adopted in consecutive time periods.
We propose a rational approach for near complete sequencing of strains related to the reference using these data and directed re-sequencing.
The design of oligonucleotides for gene silencing requires a rational method for identifying hybridization-accessible sequences within the target RNA.
A rational methodology for specific and selective peptide sequence prediction is required.
