Sentence examples for a rational progression from inspiring English sources

Combining demethylating agents with HDACi and then with cytotoxic therapy is a rational progression because epigenetic treatments could offer improved access for cytotoxic agents to the target DNA/protein complex thus allowing them to work synergistically.

Bloch gave us the first insight into the role of oxygen and sterol features affecting sterol competency and biosynthesis, while Ourisson and Rohmer provided a blue print for a rational progression in time for the biosynthesis of terpenes to hopanoids to true sterols, which starts in prebiotic systems.

There's no rational progression to advanced learning in the subject.

In keeping with this evolution in surgical practice, SSM can be considered part of the rational progression away from conventional mastectomy.

Indeed, ILCs have been separately associated with tumor-promoting as well as tumor-suppressing activities, raising the need to understand the mechanisms by which these cells regulate tumor growth and progression toward a rational design of therapeutic approaches.

Our understanding of expression patterns and their significance, is beginning to explain the nature of disease progression, and offers a rational basis for the selection of biomarkers that may be used to predict disease status and prognostic outcome.

Moreover, angiogenesis is required for tumor metastasis and progression, and thus represents a rational target for therapeutic intervention [ 34].

Determining the mechanism(s) underlying this reduced tumor progression in the old might have implications for a rational design of age-adjusted therapy.

Taken together, our data implicate activated p38MAPK in disease progression and suggest that its inhibition may represent a rational strategy for therapeutic intervention in the polyglutamine disorders.

The CXCR4 gene plays a major role in progression and metastasis of various tumor types and is, therefore, a rational target for breast cancer therapy.

He is a rational actor.