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Co-targeting the AR simultaneously with HSP90 or HSP27 is also a rational combination strategy: results from phase II trials combining the HSP90 inhibitor AT13387 (NCT01685268) or the HSP27 inhibitor OGX-427 (NCT01681433) with abiraterone will be enlightening (Table 1).
Here stands for a rational combination of -fold Lie brackets in and.
The excellent electrochemical performance can be attributed to a rational combination of two electrochemical active materials.
In order to search effective FXa inhibitors, a rational combination strategy containing molecular docking and pharmacophore model based on the known FXa inhibitors was adopted in this study.
Computational results indicated that a rational combination of the anions and cations allows designing ILs able to dissolve with different selectivity lignin and cellulose.
It paves the way of designing oxide-based high-performance supercapacitors by a rational combination of inorganic nanowires with highly conducting CNTs.
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In practice, most security forces use a more "rational" combination of race and other appropriate criteria, based on reliable statistics.
The parametric investigation indicates that the process performance could be improved by a proper and rational combination of the reactor temperature and the steam-to-carbon ratio.
In this context, engineering moves from being an analogy of the rational combination of genes as in standard molecular biology and biotechnology to becoming a veritable methodology with which to construct complex biological systems from first principles".
When three drugs are required, the most rational combination appears to be a renin angiotensin system blocker, a dihydropirydine calcium antagonist, and a diuretic at effective doses [ 8].
The available evidence supports the emerging utility of heparanase inhibition as a promising antitumor strategy, specifically in rational combination with other agents.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com