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The places for the two best runners-up are determined by a rather complex method.
As aCGH is a rather complex method, we translated the BRCA1aCGH profile to a Multiplex Ligation-dependent Probe Amplification (MLPA) assay, to identify both BRCA1-mutated breast cancers and sporadic cases with a BRCA1-likeaCGH profile.
As the aCGH assay is a rather complex method, requiring a reasonable amount of high quality DNA and specialized equipment, we endeavoured to devise an alternative method to determine the BRCA1-like profile in breast cancers suitable for routine use in pathology laboratories.
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Our choice on these two steps have been oriented toward rather complex methods: SVM based on eight component vector (color + texture) for the recognition of a road area and SURF based on 64 component vector for the description and tracking of characteristic points inside the tracking windows.
Their engine makes recommendations based on a rather complex algorithm that combines multiple methods into a single "Match Rank" — collaborative filtering (user ratings/reviews), a viewer's history, and analyzing the video's meta data.
Genome annotation is a rather complex process that can be facilitated with computer-based methods but ultimately requires extensive manual curation.
We demonstrated the usability of this approach using the COPASI implementation of the CSP method for a simple one-enzyme reaction and for a rather complex model of yeast glycolysis [ 16].
Drug testing in hair usually requires a rather complex sample treatment before drugs are amenable to analysis by either immunological and/or chromatographic coupled to mass spectrometry methods.
However, World3 is a rather complex model.
The results show a rather complex picture of the relationship.
Biofuels supply chain comprises a wide set of activities involving a rather complex set of parameters.
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CEO of Professional Science Editing for Scientists @ prosciediting.com