Human ether-a-go-go related gene (hERG, KCNH2) potassium channels mediate the rapid activating delayed rectifier potassium current (IKr) in ventricular myocytes.
These effects can be additive if the activation of nuclear receptors increases the expression of a signaling protein such as NOS or a kinase which can be activated by a rapid signaling pathway that is activated by estrogen.
As TdP is frequently associated with QT-interval prolongation due to inhibition of the rapid activating delayed rectifier potassium channel in the heart (hERG channel), the properties of such blockers were investigated by molecular modeling and semi-empirical AM1 molecular orbital calculations.
Ms. Kearns said that, in response to the reports, the consumer protection agency in Brussels had activated a rapid alert system, notifying the 27 members of the European Union and asking national regulators whether they had any information on such incidents.
After a report is received, a rapid response team is activated to deliver appropriate care while preserving confidentiality.
The subcutaneous administration of the cytotoxic Y. pestis strain appears to activate a rapid and potent systemic, CTL-independent, immunoprotective response, allowing the organism to overcome simultaneous coinfection with 10,000 LD50 of virulent Y. pestis.
In the case of pancreatic islet cells, we speculate that the glucose-regulated miRNAs could be envisioned as vital components of a rapid physiological response mechanism activated during nutrient-induced insulin secretion.
Recent findings have shown that Hsp70 binds various Toll-like receptors (TLRs) and elicits a rapid intracellular Ca2+ flux, activate NF-κB and thereby up-regulate the expression of pro-inflammatory cytokines and chemokines [22], [23], [24], [25], [26].
DDR signal activates a rapid signal transduction pathway, regulating the cell fate based on the damaged cell condition.
Once a patient's status is evaluated as critical according to these criteria [ 1], a rapid response team is activated to more thoroughly assess the patient's physical condition and to initiate treatment [ 2].
For instance, when fast growing cells are subject to amino acid starvation, inducing the stringent response [ 29], the ppGpp synthetase activity of RelA is activated, with a rapid accumulation of ppGpp.
