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The exact mechanisms of DNMT upregulation remain unclear, but it is suggested that aberrant DNMT activity, especially with regard to DNMT1, is due to a rapid proliferation of cancer cells because DNMT1 binds to proliferating cell nuclear antigen (PCNA) [ 60].
Such a rapid proliferation has been actively encouraged by the federal government, particularly by the Department of Homeland Security after 9/11, and by the Defense Department.
New York saw a rapid proliferation of bike lanes under Michael Bloomberg's tenure as mayor, as well as the introduction of the hugely popular Citibikes.
It did produce a rapid proliferation of new species as land animals adjusted to the environmental shifts.
It led to a rapid proliferation of trade union membership from 9m to 12.2m, the largest trade union movement per head of the working population of the western world.
The success of Disneyland, as well as the city's aggressive efforts to create what it says is the West Coast's largest convention center, led to rapid urbanization as well as a rapid proliferation of visual blight.
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The transfer of OT-1 CD8+ T cells to lymphopenic hosts (Rag1-deficient recipient mice) results in a relatively rapid proliferation of transferred CD8+ T cells in the absence of antigen.
The arsenic-transformed cells showed a more rapid proliferation rate in complete medium than did control cells and also showed sustained proliferation in steroid-reduced medium.
Very early tumours that grow very slowly may be resected later than offspring from this tumour that has a more rapid proliferation (van Tilborg et al, 2000).
The original "Cops" series made its debut more than 20 years ago, but police shows are the hottest genre in reality television, Ms. Ouellette said, mainly because they are cheap — a perfect product for a time of rapid proliferation of cable channels in need of content but ever-shrinking production budgets.
Furthermore, because cancer cells generate reactive oxygen species (ROS) as a consequence of rapid proliferation, activation of mechanisms to sustain the balance of the intracellular redox level is a key component of metabolic adaptation.
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