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A rapid correction was defined as any increase in [Na+] ≥ 12 mmol/L after 24 h [11].
Selective chloride (Cl-) removal, by increasing SID in an alternative way, may allow a rapid correction of acidosis without altering plasma osmolality and Na+ concentration.
Conclusion In the context of acute severe H-Na induced by fluid resuscitation, a rapid correction rate might be associated with even aggravated rather than improved mortality.
Experts recommend a rapid correction of acute (<2 days) and sever (> 150 mmol/l) H-Na with a rate of −2 mmol/l/h until Na < 146 mmol/l (1).
Given the different pharmacokinetics and smaller distribution volume, the administration of calcifediol should be preferred in conditions characterized by impaired 25-hydroxylation, obesity, and malabsorption, and when a rapid correction of vitamin D status is needed in order to begin an antifracture treatment [120] (grade B recommendation).
53 HAF offers the opportunity of a rapid correction of nodules, etc, by the use of hyaluronidase injection.
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Hyponatraemic seizures may be resistant to anticonvulsive therapy and may require a more rapid correction by a 3% saline bolus of 3 to 5 ml/kg followed by fluid restriction [ 27].
Thus, if an overly rapid correction of a hypotonic state occurs, the cells may not be able to effectively respond to osmotic changes and water moves into the extra-cellular space [ 15].
Osmotic demyelination syndrome (ODS) is an uncommon disorder, characterized by non-inflammatory demyelination involving the pons and other areas of the central nervous system, which may occur for instance as a consequence of an overly rapid correction of hyponatraemia [ 1].
Also, this technique probably permitted a more rapid correction of metabolic acidosis by acting on the renal component of this disorder.
We reported here a case of ODS occurred in a pregnant woman with hyperemesis gravidarum after an overly rapid correction of low serum [Na+] in the presence of several concomitant risk factors.
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