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Although progress has been quite slow, recent advances in gene editing could lead to a rapid application of gene drive approaches to other species, Oye and his colleagues predict.
SR Ca2+ load was estimated by a rapid application of 10 mM caffeine via a nearby pipette.
Furthermore, a rapid application of the calcium ionophore, A23187, caused the fluorescence to greatly exceed that produced by glutamatergic stimuli (Supplementary Fig. S4; Supplementary Movies 4 and 5).
Mobilization typically involves a slow and sustained application of iatrogenic force, while manipulation is characterized by a rapid application of iatrogenic force.
SR Ca content was quantitatively measured by a rapid application of 10 mM caffeine and integration of the resulting inward NCX current.
After the learning phase, tube 6 was modified: TdT was replaced by CD36, as TdT had not contributed to suitable independent LAPs, did not appropriately function as an exclusion marker for M4 and M5 AML types, and, as intracellular marker, hampered a rapid application of the panel.
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Although such frameworks have a rapid application run time, the testing of new workflows and concepts is cumbersome because programming requirements are high, and edit-compile cycles are slow.
A high level of suspicion, aggressive diagnostic measures, and the rapid application of an effective therapy are essential if we are to improve the mortality rates for these diseases.
This notion is supported by the inhibitory effect of rapid application of a low [Na+]e solution at physiological (this study) and ambient (reported previously [13]) temperatures.
Fig. 1A shows a recording of the effect of rapid application of 5 μM KB-R7943 on spontaneous APs from a representative AVN cell.
To confirm this, the SR load was probed by rapid application of 10 mM caffeine, following a 10 s suspension of pacing.
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