Phase I trials (300 participants) were performed to establish immunogenicity and tolerability of a range of doses of monovalent HPV L1 vaccines.
Phase II trials (3,500 participants) were performed to establish the immunogenicity and tolerability of a range of HPV L1 VLP vaccine dose formulations and provide preliminary proof of concept.
The aim of the current study was to evaluate the efficacy, safety, and tolerability of a range of doses of taspoglutide, given either once weekly or once every 2 weeks, in patients with type 2 diabetes inadequately controlled with metformin alone.
During the following 7 weeks, the recommended atomoxetine dose was 1.2 mg/kg per day, which could be adjusted within a range of 0.5 – 1.4 mg/kg per day, depending on effectiveness and tolerability.
This dose could be adjusted within a range of 0.5 1.4 mg/kg BW per day, depending on effectiveness and tolerability.
During the following 7 weeks, the recommended target dose was 1.2 mg/kg BW per day, but could be adjusted within a range of 0.5 1.4 mg/kg BW per day, depending on effectiveness and tolerability.
The study also confirms the effectiveness and tolerability of this antibiotic for patients with a range of cSSSIs when used in accordance with the approved summary of product characteristics [ 20] and appropriate local guidelines.
Important considerations for elderly patients include tolerability, absence of drug interactions, and the availability of a range of dosages to tailor treatment to individual patients.
This study is novel in that a range of different outcomes were brought together, including efficacy (relief of pain, physical functioning, PGA), tolerability (withdrawals), and most commonly studied risks for NSAIDs (GI and CV).
Conversely, it may reflect a true lack of tolerability of beta-blockers in patients who are typically relatively old, have co-morbidities, and are taking a range of other drugs.
