The phrase "a range of prion" is not correct in written English.
It should be "a range of prions" to refer to multiple types or variations of prions.
Example: "The study examined a range of prions to understand their different effects on the brain."
Alternatives: "a variety of prions" or "multiple types of prions".
To explore the possibility that CJD, and not amyloid-β seeds, was the culprit, Collinge and colleagues also examined the brains of 116 people with a range of prion diseases unrelated to the hormone injections.
We ran simulations over a range of prion survival rates, γ (weekly survival probabilities: 0.9481, 0.9868, 0.9967, 0.9978, 0.9983, translating to half-lives of 0.25, 1, 4, 6, and 8 years, respectively).
PIB scans were negative in three small series featuring a range of prion disorders, including sporadic Creutzfeldt-Jakob disease, variant Creutzfeldt-Jakob disease, and a range of prion protein mutations [ 83, 84].
Hence, we chose a wide range of prion survival values over which to simulate.
Moreover, an inverse relationship was observed between the dose of prion inoculum administered and the point of bioluminescence inflection that was observed, relative to mock treated mice, over a wide range of prion dilutions.
This suggests a role in a fundamental aspect of prion disease as these genes were initially identified with human prion strains in case control studies which may be measuring a range of susceptibility factors including for example uptake of prions from the environment or periphery which are not measurable in this assay.
A range of antibody fragments with anti-prion activity has been derived from murine anti-PrP antibodies [26] and a few antibody fragments were already isolated from combinatorial phage display libraries expressing human scFvs [27], [28].
These results are interesting as they show that either the range of prion diseases and associated pathology is still wider than previously thought or that substantial abnormalities of prion protein expression may be associated with brain lesions unconnected with classical prion diseases.
Sheep scrapie represents a unique diversity of prion disease agents in a range of susceptible PRNP genotypes.
A level of significance across a range of studies representing different hosts and prions strains suggests that Stmn2 may well be worthy of further investigation.
Overall, the influence of solution chemistry on prion desorption and replication was slight in this study, especially in short term experiments (≤7 d), and our results indicate that prions bound to soil in contact with a range of solution chemistries could remain a risk for transmitting prion diseases after long periods in the environment.
