In the 1970s, the development of monoclonal antibodies from mouse cells, by Kohler and Milstein, created great excitement over the possibility of producing "magic bullets" to cure a range of hitherto intractable diseases.
Similarly rapid advances in our understanding of the genetics and basic chemistry of the brain have raised the prospect of genuine breakthroughs across a range of previously intractable neurological disorders, and are promising fresh insights into psychological conditions like schizophrenia and autism.
Paclitaxel (PTX), introduced into the clinic in 1991, has revealed itself as an effective antimicrotubule drug for treatment of a range of otherwise intractable cancers.
We selected genes with the reported criteria [15]: not only were these selected genes conservative enough for primer design, but they were also parsimony informative for the resolution of a variable range of intractable phylogenetic problems.
Yet even if the government could find the money to pay for the unfunded pensions, perhaps through bond issues, setting up a funded system would require it to tackle a range of other equally intractable issues.Pension funds need efficient capital markets in which to invest.
On a range of fronts, high ambitions are colliding with intractable realities on the ground.
Last month in Leonhart's formal hearings, Sen. Herb Kohl questioned Leonhart to clarify her policy concerning new legislation to permit nurses in long-term care facilities to prescribe a range of anodynes including morphine to patients suffering intractable pain.
The event was the result of several meetings in Helsinki, Finland, attended by a range of Iraqi politicians, as well as veterans from two other seemingly intractable conflicts, in Northern Ireland and South Africa, who have gone on to become political leaders.
Black IOLs are indicated in patients with intractable diplopia, visual confusion, unsightly leucocoria and a range of neuro-ophthalmic disorders.
A Range of Arrangements Q.
