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Although the study was not powered to compare efficacy outcomes statistically, the ASA404 combination appeared to improve a range of efficacy end points compared with carboplatin and paclitaxel alone – most notably overall survival.
Using a case study in rheumatoid arthritis this paper presents a MTC model on a range of efficacy measures illustrating the increased power of continuous outcome measures in such models compared to using binary measures.
A range of efficacy endpoints were assessed in the individual studies, but only trough FEV1 measured at the end of a dosing interval (the primary endpoint in studies HZA106827 and HZA106829 and a secondary endpoint in study HZA106837) was analyzed in the Japan subgroup, as pre-specified in the analysis plan.
To demonstrate how the model can be used to explore the impact of treatments with a range of efficacy, we provide an example of a hypothetical treatment (TREATMENT A) that decreases the development of asymptomatic pre-clinical coronary artery and carotid artery disease by an unknown amount.
As a feasibility study, especially in a patient population that has been the focus of very few randomized controlled trials, no primary endpoint was prespecified; rather, a range of efficacy measures was identified and evaluated at three months in comparison to baseline.
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In both cases, the outcomes have been plotted over a range of efficacies for the single immunogen comparator vaccine.
If a range of efficacies were given or different efficacies given for different disease serotypes, we used the average efficacy.
A number of influential studies have confirmed that SGAs outperformed FGAs in a range of clinical efficacy parameters, including the domain of social cognition [ 32, 36, 44– 44].
In contrast, multiple changes in miRNA abundance can occur in vivo [ 32], where simultaneously up-regulated and down-regulated miRNAs can target the same gene but with a range of predicted efficacies [ 25].
Our analysis includes therapies available over a period of 40 years that demonstrated a wide range of efficacy levels.
However, detailed examination of 474 individual protected areas unveils a broad range of efficacy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com