In a random screen of small molecules, Kitambi et al. recently identified novel molecules inhibiting hyaloid angiogenesis in zebrafish larvae [21].
A random screen of 564 yeast strains, each lacking a single nonessential gene, implicated both TOR1 and SCH9 in RLS downstream of caloric restriction.
A random screen of 20 organic man-made chemicals present in liquid effluents revealed that half appeared able to interact with the estradiol receptor.
In the context of a random screening assay, however, the parallel determination of intracellular eYFP intensity in a screening assay can serve to identify compounds which do not specifically interfere with HIV particle formation but rather exert a general effect on protein expression.
Instead, a random screening approach allowed the identification of short peptide aptamers that bind specifically to mutant p53 and, importantly, trigger cell death in breast cancer cells expressing mutant, but not wt, p53 (145).
The targeting of virulence systems of pathogens, by rational drug design against a given target, or by random screening of a library of compounds inhibiting the transport of the virulence system, is a new strategy [37], [47].
We also developed and tested a kinase-focused library based on our kinase-likeness score and showed its superior enrichment for three specific kinase targets from different branches of the human kinome, relative to random screening of a collection of compounds.
Microbially based natural products discovery programs have traditionally relied on the random screening of a pool of novel biodiversity (i.e., new microbial species) to secure a source of structurally novel small molecules.
Following the Sept. 11 attacks, Greyhound officials instituted a series of security measures, including random screening of passengers and carry-on luggage at many bus terminals around the country.
