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Loss of Stat3 expression in mouse embryonic fibroblasts (MEF) drives increased Rac1 activity, and this promotes a random mode of migration by reducing directional persistence and formation of actin stress fibers [34].
Similarly, loss of STAT3 expression results in a random mode of migration, while STAT3 modulates Rac1 activity to maintain directional persistence during migration [ 65].
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The simulation scenario consists of a BS and several SSs distributed around the BS in a random mode.
Then OptiCells containing subconfluent monolayers were fixed onto the RPM, as close as possible to the center of the platform, which was rotated at a speed of 60°/s using the random mode of the machine.
Then, a single collision (or channel error) is not enough to move a station from the deterministic mode of operation to the random mode of operation.
In CSMA/E2CA, a station that suffers two consecutive unsuccessful transmission attempts switches to the random mode of operation.
Along this vein, several previous studies implicated the random mode of cell migration in tumor progression.
Conceivably, by regulating microtubule dynamics, NAV3 inhibits the random mode of cell migration and restrains dissemination of tumor cells.
This study identifies NAV3 as a suppressor of breast cancer progression and proposes that the ability to stabilize microtubules and inhibit the random mode of migration restrain metastasis.
In other words, the quantitative modeling we performed implied that loss of NAV3 would bias the random mode of cell migration.
A fungal PME from Aspergillus aculeatus (Aa-PME), with a pseudo-random mode of action, was used to demethylesterify a extremely high methylesterified HG (DM 94%, average degree of polymerization 246) by reducing the degree of methylesterification (DM) from 94% to either 70% or 80%.
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