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The phrase "a puzzling increase of" is correct and usable in written English.
It can be used when discussing an unexpected or confusing rise in a particular metric or phenomenon.
Example: "The researchers reported a puzzling increase of cases in the region, prompting further investigation."
Alternatives: "an alarming rise in" or "a perplexing surge of".
Exact(1)
We found a puzzling increase of resistance by downregulated genes, as one would think that "procuring armaments" is the best defense.
Similar(58)
A puzzling observation of our study was that the increase in SDHA protein with endurance training in normoxia (Fig. 4a) was blunted with endurance training in hypoxia (Fig. 3b) and correlated negatively with the fold changes in Pmax (Fig. 4).
Kessler points to a puzzling aspect of Rice's record.
In the next fight, an Iranian boxer, Ali Mazaheri, was disqualified, after a puzzling flurry of warnings.
BARACK OBAMA invited a puzzling group of people into the White House on December 5th: university presidents.
For the casual observer, it may have been a puzzling set of comments.
From a philosophical perspective, neoliberal assimilation involves a puzzling mix of economic liberalism and cultural conservatism.
The work helps explain a puzzling pattern of extinction in mammals.
Buderus, too, is a puzzling source of irritation to the feisty Frenchmen.
This leaves us with a puzzling view of Bergdahl.
This leads to a puzzling situation of where to find the likely local causative genes.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com