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Among French composers Saint-Saëns was a decisive force in a purposeful shift from opera and other dramatic entertainments toward ostensibly more exalted absolute forms like the symphony and the sonata.
Immune suppression, at least in newborn mice, appears to reflect a purposeful shift in the balance of immune cells.
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Critical perspective to the futures focuses on a purposeful transformation and development of an existing situation.
With every purposeful shift, Crosby gave fans — many wearing giveaway T-shirts that, referring to Crosby's comments after Game 3, said, "Guess what?
A purposeful sample of 15 patients who shifted from heavy smoking (20 40 cigarettes per day) to low moderate levels of smoking post treatment were followed for an additional 12 months.
The situations are so similar that they are speaking mostly the same dialogue, often in tandem, a purposeful, trenchant and amusing parallel that suddenly shifts when Leon and Jane go through with the infidelity and Pete and Sonja do not.
The Bush administration is making a purposeful effort to bankrupt the government so as to eliminate entitlement programs or shift them to religious groups regardless of their fitness to run these programs.
The field has since shifted toward developing materials that interact with biological systems in a purposeful way.
A purposeful run.
It's a purposeful death.
She affects a purposeful tone.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com