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The serotonin precursor 5-hydroxy-l-[β-11C]tryptophan ([11C]HTP) is in clinical use for localization of neuroendocrine tumors and has been suggested as a proxy marker for pancreatic islet cells.
The high inter-correlations suggest that the PGC can also act as a proxy marker for mood and hence depression, as has been done in some studies [7].
The induction of metallothionein genes has been used previously as a proxy marker for copper excess, and Ctr1B induction as a marker for copper deficiency [15].
The validation of IGRAs to detect LTBI suffers from the lack of gold standard, so active TB disease has often been used as a proxy marker for LTBI [4].
Likewise, while it is known that both TNF-α and IFN-γ are essential for controlling mycobacterial infections [8] [11], the use of either factor alone as a proxy marker for disease or immunity has been unsatisfactory [12], [13].
This will be used as a proxy marker for poor mobility or frailty.
Similar(38)
We therefore assessed parasite densities as a proxy marker of fitness.
There may also be simultaneous coexposure to other environmental chemicals that contribute to the effect on testicular descent; the pesticide measurements may represent a proxy marker (sentinel) for other exposures, such as brominated flame retardants.
The ratio of the lengths of the second and fourth digits (2D∶4D) is a sexually differentiated trait believed by many to be fixed in utero, and thus, a possible proxy marker for prenatal androgen activity.
Further study is needed to identify biomarkers for those more toxic compounds or to establish whether TCAA is a valid proxy marker for any of them, Richardson says.
In addition, the notion of 'race' itself is often used as a crude proxy marker for presumed biological and social differences, and therefore, research in this area would be better informed with social science input 203.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com