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More worryingly, there's a proven effect on productivity.
In contrast to the high expenditures, significant progress in the treatment and prevention of osteoporosis has been achieved in the past two decades with the development of different compounds with a proven effect on bone mineral density and reduction of fracture risk [34 36].
Indeed, interventions studied in randomized trials with a proven effect on outcome in ALI have required a large number of patients [ 32, 33].
In South Africa, the country with the largest number of people living with HIV and the biggest treatment targets, an intervention with a proven effect on testing uptake should be considered for scale-up.
Under current guidelines from regulatory agencies, new drugs can be granted market authorization in the absence of a proven effect on OS if trials have demonstrated a substantial PFS benefit and SPP is long.
The decision for cidofovir was based on the conception that a second antiviral drug with a different mode of action (acyclic nucleoside phosphonate without the need for activation by the viral thymidine kinase) [ 9] and a proven effect on many herpesviridae [ 10] could favorably influence the course of the disease.
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She could ignore the new pay-for-performance plans that linked reimbursement to quality measures with little proven effect on patient outcomes.
Yet despite being the third biggest-selling supplement in 2009 with sales of £68m in the UK, glucosamine has no proven effect on osteoarthritis and is not recommended by the National Institute for Health and Care Excellence, which produces guidelines on treatment for the NHS after reviewing the best research.
We studied five drugs with proven effect on GABAergic transmission: Topiramate, Valproate semisodium, Gabapentin, Lamotrigine and Levetiracetam.
This obstructed the analysis some, but we can conclude that there is no visible, statistical proven, effect on the 125I-EGF – EGFR interaction when the SKBR3 cells are exposed to either starvation or gefitinib.
In conclusion, antiviral treatment for HBV has no proven effect on the clinical outcomes, HCC and mortality.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com