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This treatment, rather than killing disseminated metastatic cells, should induce a protracted state of dormancy and prevent overt metastases.
Interestingly, dormancy of DTCs in the bone marrow may depend on the activation of tumor growth factor-beta signaling and p38 activation, p53 induction, and ERK inhibition in D-HEp3 cells, indicating that microenvironment-derived signals that impinge on stress signaling pathways might be sufficient to induce a protracted state of cellular tumor dormancy [ 8].
The country remains in a protracted state of chaos with two governments fighting each other, while Isis militants have gained a toehold in the growing security vacuum.
The ensuing civil conflicts of 1996 and 1998 have led to a protracted state of violence, claiming over five million lives since 1996[ 10].
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But when this protracted state of narrative lassitude suddenly shifts, "Pirates" brings in enough story line for several movies.
"I also firmly believe that Michael Appleton's departure is a direct result of his frustration at the protracted state of affairs".
Ongoing and unbounded spying is consistent with the protracted state of war America has produced in the country.
Before flying to South Carolina on Sunday, Mr. Obama's appearance at Ebenezer Baptist in Atlanta offered a glimpse into the next phase of the campaign, which almost certainly is shaping up to be a protracted state-by-state fight.
This may suggest a protracted process of hominin adaptation to these emerging, more open landscapes.
Although Xenopus tadpoles go through a protracted larval state, the ossification of the frontoparietal bone, the major constituent of the skull, takes place from approximately stage 54 to 64 and initiates from lateral ossification centers.
As Secretary of State, Hillary Clinton maintained a protracted correspondence with Wilson, then a consultant for Symbion Power an energy company that specializes in risky markets like Iraq, Afghanistan, and, recently, Sub-Saharan Africa. Sub-Saharan Africa
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CEO of Professional Science Editing for Scientists @ prosciediting.com