What might work, when public interest demands but consent is not possible, are schemes that separately copy just the minimum of phenotype and genotype data from various health management systems for a specific group of vetted researchers working within a highly protective legal context.
In this context, a protective effect of some polyphenols against amyloid cytotoxicity was reported.
In this paper, two related issues were explored: whether placement changes (i.e., moving between foster homes or from a foster home to a permanent placement) were associated with more blunted daily cortisol rhythms and whether a caregiver-based intervention exerted a protective effect in this context.
Contrary to these reports, a recent study found that myofibroblasts may serve a protective role in the context of pancreatic cancer as depletion of myofibroblasts and fibrosis in a mouse model of pancreatic ductal adenocarcinoma leads to a more invasive cancer cell phenotype and reduced survival [40].
Moreover, some cytoadherence phenotypes, such as adhesion to CD36, have been associated with uncomplicated malaria [22], [24], [29], suggesting a protective role in the context of severe disease [30], [31].
Sequestration of misfolded proteins in MCF10A cells has a protective role in this context.
In this context, a protective effect of anti-S-layer protein serum has also been observed in a lethal hamster challenge model.
Here, we speculate on the potential utility of EPO as a protective cytokine in the context of acute critical illness and suggest key parameters required for a proof-of-concept clinical study.
Further studies with school-aged children found that self-regulation moderated the association between socio-contextual family adversities and mental health outcomes, signifying the potential role of self-regulation as a protective factor in the context of family adversity [ 43, 52].
