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Furthermore, such an approach is not practical to apply as a prospective prediction because of the lack of information about the contributions each transporter made to the total uptake.
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It is worth mentioning that the limited number of samples of tissue phantoms (24) does not allow us to create a true prospective prediction set.
A sample was denoted 'positive' if the observed to expected ratio exceeded 1, and a similar prospective prediction of the presence of underlying colorectal neoplasia was declared, prior to breaking the identifying sample code.
Salivary cortisol alone may be too crude a measure for prospective prediction and a more comprehensive approach may be required.
A model developed in such a way would permit prospective prediction of the 4βHC biomarker response in clinical studies based on preclinical data.
The prospective prediction models had lower predictive R-squares than the concurrent prediction models.
We have presented two prediction models for drug responses in breast cancer patients: (1) an unsupervised clustering-based retrospective prediction and (2) a drug-sensitive centroid-based prospective prediction (Table 6).
Taken together, these findings represent an alternative method toward the prospective prediction of healthcare costs in pediatric federally supported managed care populations.
In order to construct a reference drug-sensitivity signature for individual prospective prediction, we used the Sanger Genomics of Drug Sensitivity (GDS) dataset containing hundreds of annotated human cancer cell lines [ 33].
Similar to the concurrent prediction models, the prospective prediction model which combined ADGs and Rx-MGs had a predictive R-square (0.382) that was higher than those using either ADGs or Rx-MGs.
Given our finding that the top two prognostic signatures can retrospectively predict some common chemotherapeutic outcomes in breast cancer patients (Table 5), we designed an algorithm using the BRmet50 and PMID18271932Sig33 predictors for prospective prediction of taxane-anthracycline sensitivity in individual patients with HER2- breast cancer.
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