Although all patients were treated with sorafenib according to a prospectively designed regimen, the study was not designed as a prospective phase II trial.
Rosinol, L. et al. Bortezomib, Lenalidomide and Dexamethasone (VRD-GEM) as induction therapy prior autologous stem cell transplantation (ASCT) in multiple myeloma (MM): results of a prospective phase III Pethema/GEM Trial.
With the goal of identifying determinants of response, we performed molecular characterization of tissues and circulating tumor DNA (ctDNA) from 61 patients with mGC who were treated with pembrolizumab as salvage treatment in a prospective phase 2 clinical trial.
We designed a prospective phase I/II trial of erythropoietin neuroprotection in neonatal cardiac surgery to assess safety and indicate efficacy.
To investigate clinical feasibility and toxicity of combined photon and carbon ion radiotherapy in locally advanced adenoid cystic carcinomas (ACC) within a prospective Phase I/II trial.
This is a prospective Phase 2, single-center, multi-allergen OIT in participants with proven allergies to up to 3 different foods in which one must be a peanut.
METHODS AND MATERIALS: This was a prospective Phase I/II trial.
Outcomes of unrelated donor cord blood transplantation in 191 hematologic malignancy children (median age, 7.7 years; median weight, 25.9 kg) enrolled between 1999 and 2003 were studied (median follow-up, 27.4 months) in a prospective phase 2 multicenter trial.
Briefly, a prospective phase 1a, single blind, randomized, placebo controlled, dose-escalating study was conducted in 46 healthy malaria-naïve adult volunteers.
Although the rhAPC APACHE II >25 sub-analysis remains beneficial in the moderate skeptic analysis, the original results have not been validated in a prospective phase III trial yet.
Further studies may be needed to increase the number of BE progressor and non-progressor specimens by collecting specimens from multiple additional institutions prior to initiating a prospective Phase 4 study.
