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Despite the limitations of the study and the fact that a proportion of study patients received sub-optimal ART before being switched to HAART, the significant reduction in TB disease observed is all the more remarkable.
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In addition, to the numbers that cease a proportion of studies also reported the number of cats that reduced spraying relative to baseline [2], [5], [6].
The number of cats living within each multi-cat household varied, for example, Frank et al. [2] reported a range of 2 14 cats per household with a mean of 4.5 and a median of 3. A proportion of studies only recruited cats from multi-cat households with ≤ 4 cats [18], [21], [33].
Finally, given that a proportion of studies included are retrospective, a possibility of residual confounding by unmeasured factors cannot be eliminated.
It may also be costly and time-consuming to obtain, or only available from a proportion of studies (Riley et al, 2007a, 2008).
Many studies characterized ETEC isolates by toxin types, that is, those that elaborate heat-stable or heat-labile enterotoxin only, or those that produce both; a proportion of studies serogrouped Shigella isolates.
In practice though, IPD may only be available for a proportion of studies, and so methods for multivariate meta-analysis are required that combine IPD and aggregate data [ 27, 28].
Likewise, significant effect size variation was found between metric subtypes (QM = 49.18, p < 0.001) indicating that in a proportion of studies heterogeneity can be related to the community composition endpoint assessed.
Also, information regarding CRD status was incomplete for a proportion of the study sample.
Additionally, we had information on prostate volume and BMI for a proportion of our study population.
It is possible that a proportion of our study participants might not have actually been exposed to SARS-CoV.
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