However, seroconverters were female in a larger proportion of linked relative to unlinked pairs (46.3% versus 27.5%, p = 0.04).
A larger proportion of linked women (84%) than of questionnaire responders (78%) were still resident in Aberdeen while the reverse held for residence in the UK but outside Scotland (2% versus 11%).
Out of those 20%-40 20%-40e familial melanoma is linked to chromosome 9p21 locus and a proportion of 9p21 linked families carry disease-segregating germline mutations in cyclin-dependent kinase inhibitor 2A (CDKN2A) gene [ 7].
Furthermore, there was a trend toward the proportion of linked transmissions being greater among seroconversions identified at the first 3-month study visit compared to seroconversions identified after 3 months (89.5% versus 66.9%, p = 0.06).
3. It is intriguing that we were unable to identify a species bearing equivalent proportion of linked and unlinked tandems, since FISH studies confirmed homogenisation across all rDNA loci.
The LOD score test statistic was used to estimate the proportion of linked families and the corresponding maximum heterogeneity LOD score.
The high proportion of linked cases with lineage-2 could reflect few imported (and therefore unlinked) cases, although there was no association between lineage and immigration.
Nevertheless, a proportion of melanoma families linked to the 9p21 locus do not harbour germline mutations of INK4a-ARF, and three large deletions have been reported in hereditary predisposition to melanoma and nervous system tumours, two involving both p16 INK4andnd p14 ARF (Bahuau et al, 1998), and one restricted to exon 1 β of p14 ARF (Randerson-Moor et al, 2001).
A fixed number of local links (representing a proportion of all local links) is selected and those connections are 'rewired' to a random location outside the interaction neighbourhood determined by r i (0 ), thus keeping the total number of links (local and long-range) constant.
Expressed as a proportion of possible tip link sites (i.e. tip-side appositions) the homozygote had fewer occupied sites (30%) compared with the heterozygote (46%), fewer unforked links (23% vs 47%) and fewer stumps (5% vs 9%) but more ambiguous links (65% vs 38%).
