Clade II block frequency, as a proportion of total copy number, showed a cline with the highest frequency in East Asia and lowest frequency in Africa (Table 2, Supp. Table S4, and Fig. 4).
However, this limitation is eased in the case of whole-exome capture, where a large proportion of copy number neutral regions can be achieved.
Increasingly, CNV has been shown to be important both for human diversity (Redon et al. 2006) as well as disease susceptibility, e.g. in autism and schizophrenia (Pagnamenta et al. 2009) as a significant proportion of copy-number variants can cover millions of base pairs of DNA and encompass many genes and their regulatory regions.
The results from the Cox proportional hazard regression model, considering each score as a continuous variable, showed that an increasing proportion of copy gains within " exclusively amplified regions" (class k = 7) was associated with a statistical significant high risk of relapse (p < 0.05).
> -wrap-foot> Results are shown if the proportion of copies exhibiting a mutation bias was over 10%.
In less conserved lineages, the proportion of copies with an uninterrupted ORF was typically very low, below 20%.
To assess the relationship between the total ITS2 copy number and the proportion of copies that were of type C100, a non-linear regression curve (second order polynomial) was fitted to the bivariate CC100 CTOTAL versus CTOTAL data in Sigmaplot v11.0 (Systat, Richmond, CA, USA).
For both lineages, the proportion of copies present in the same supercontig as a putative CDS was higher for MITEs than for non-MITE copies.
However, it remains unclear why transgene silencing has only been observed in a proportion of the cases where multi-copy transgene arrays have been studied.
The proportion of copies in which microstate i is found at time t is an approximation for u i (t) and this approximation becomes more accurate as the number of copies is increased.
