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A proportion of affected males (∼30% of cases) have developmental delay (1– 7).
Patellofemoral pain syndrome (PFP) is a common musculoskeletal condition that has a tendency to become chronic and problematic in a proportion of affected individuals.
We have also shown that it is more appropriate to perform MLPA analysis prior to, rather than after, point mutation analysis and that reporting times can be substantially reduced for a proportion of affected individuals.
A proportion of affected LHON carriers (33.7%, n = 66) also reported occupational or accidental toxin exposure in the immediate period preceding visual loss, which included exhaust fumes (n = 16), dry cleaning solvents (n = 13), asbestos (n = 5), lead (n = 4), scrap metals (n = 4) and fibreglass (n = 2), at high levels not encountered in a normal environment.
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The damaged tubular area was expressed as a proportion of the affected tubular area and total tubular area.
A large proportion of affected children reach a quiescent stage around early adolescence [ 1- 3].
Angelman and Beckwith-Wiedemann syndromes are two disorders in which an imprinting defect accounts for a significant proportion of affected cases, with known increased risks for children born after ART.
Multiple studies have concluded that the effects of ART procedures may be restricted to imprinting disorders, such as AS and BWS, in which methylation patterns result in the loss of expression of the maternal allele, or in which an imprinting defect accounts for a significant proportion of affected cases.
While a minor proportion of affected patients suffer from an inborn error of metabolism, in most instances hyperuricemia results from an excessive uptake of purines from the nourishment together with an enzymatic blockage of its degradation in the liver by toxic substances, such as alcohol and/or reduced excretion through the urinary system.
Patellofemoral pain syndrome (PFP), or idiopathic pain arising from the anterior knee, is one of the most common musculoskeletal conditions affecting young active adults [ 1- 6], and has a tendency to persist to some degree in a substantial proportion of affected individuals [ 7].
Here, we also found a high proportion of affected domains in both groups, with a slightly higher (though not significantly) representation of species-specific domains in the non-conserved/lost group (60% vs 47%, p = 0.09, Fisher 1-tail test; Additional file 2).
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