The article of Koopmans et al. in 2008 [ 18] included 23 patients with pancreatic islet cell tumours; 39 % of patients had biochemical proof of increased serotonin metabolism.
In 24 patients with abdominal carcinoid tumours and biochemical proof of increased serotonin metabolism, per-patient analysis showed sensitivities of 100%% for 5-HTP, 96%% for FDOPA, 86 % for SRS and 96%% for CT [ 18].
We have tested the hypothesis that increased 5-HT2C receptor signalling may be causative of anxiety and reduced activity, and provide a proof-of-principle that increased 5-HT2C receptor levels in the forebrain alter behaviour.
These results essentially provide a proof-of-principle and increase our understanding that at least initial signaling events of IgE sensitization-induced FcεRI activation are similar, if not the same, in ASM and mast cells.
This declaration, viewed as proof of increasing Indonesian Communist Party (Partai Komunis Indonesia, or PKI) power, led to conflict between the PKI and the military.
In a proof-of-concept study cortisol levels increased in scalp-near hair segment of pregnant women that corresponded to the well-known increase of blood cortisol levels in the third trimester of pregnancy [ 33].
Because our study is a proof-of-principle study we decided to increase epoprostenol infusion rate every 10 minutes with 1 ng/kg/min to the maximum dose of 8 ng/kg/min, which is substantially higher than maximum initial doses used in epoprostenol intervention trials in patients with chronic pulmonary hypertension [ 19].
A direct proof of an increased monocyte TF activity and/or antigen in septic patients is still lacking.
Using pom1 as a proof-of-principle, we observed a maximal increase of Purg1-pom1 transcripts after uracil addition within less than 30 minutes, and a similarly rapid decrease after uracil removal.
The swelling tests performed gave a proof of their application for increasing PDMS stability towards organic solvents.
Results published here, following the integration of a single phase 2 plasmid, demonstrate a proof of principle, but not an increased efficiency for site-specific integration for this particular construct.
