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However, the reduction in ROM of the inflamed knee joint represents a valuable parameter to use in the assessment of the global severity of arthritis in experimental arthritis models and appears to be well transferable to human disease states, thereby making it a promising readout parameter for the preclinical assessment of anti-inflammatory agents.
The dynamic ROM observed in freely moving rats in our model of knee joint arthritis might serve as a parameter for global disease activity and might thus represent a promising readout parameter for preclinical assessment regarding the overall efficacy not only of antiarthritic but also of antinociceptive compounds.
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As shown for the first time by Cohen-Tannoudji et al. [25] in 1967 optically pumped alkali (Rb) magnetometers are a promising alternative for the readout of the 3He precession signal.
A fast scintillator-based Compton telescope with SiPM readouts is a promising solution to this instrumentation challenge, since the fast response of the scintillators permits both the rejection of background via time-of-flight (ToF) discrimination and the ability to operate at high count rates.
Overall, these results, combined with subsequent experimental readouts, are a promising demonstration of successful synthesis of functional 23-mer PNA from PSi, with highly efficient growth of the vital anti-miR122 PNA seed sequence.
Therefore, taking advantage of the excellent optical property of CDs and the specificity of enzyme, the dual-readout platform can potentially be a promising candidate for OPs detection.
Apart from these hybrid materials, optically active quantum dots (QDs) can be considered as a promising material for the functionalization of the hydrogels, as the optical readout signal (which is the strong and photostable emission of QDs), is extremely sensitive to pH changes [35, 36].
Nanopores have emerged as a promising platform for DNA sequencing, culminating with the reports of DNA sequence readout obtained using biological nanopore MspA or α-hemolysin and a DNA-processing enzyme phi29 polymerase.
Not a promising combination.
Hardly a promising start.
A promising start.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com