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A prominent function of CAP-Gly domains is to bind to C-terminal EEY/F-COO− sequence motifs present in α-tubulin and in some microtubule-associated protein tails; however, CAP-Gly domains also interact with other structural elements including end-binding homology domains, zinc-finger motifs and proline-rich sequences.
A prominent function of chemokines is to promote the chemotaxis and activation of leukocytes.
The abundance of sPLD-like-B isoforms suggests that they have a prominent function.
Also, these SVs have been shown earlier to be unable to reach the cell surface and therefore they are unlikely to have a prominent function.
Agrin is a large proteoglycan with a prominent function at the developing neuromuscular junction (NMJ) where it plays a pivotal role in the formation and maintenance of the acetylcholine receptor (AChR) clusters.
Collectively, these findings underscore that DC-derived RA has a prominent function in the regulation of gut-associated immune processes.
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Of the array of signaling events activated in response to VEGF and cell adhesion, the Ras/Raf/MEK/ERK1/2 pathway is known to play a prominent role in EC function [3], [4], [5], [6], [7].
The expression pattern of G-CSF ligand and its receptor combined with its strong trophic activity and signalling prerequisitions indicate a prominent role in hippocampal function for G-CSF.
ECs not only function as a barrier- producing an interface between circulating blood and the perfused tissue- but also play a prominent role in tissue functioning as well as organogenesis.
Psychosocial factors play a prominent role in sexual functioning, and diminished sexual interest and sexual abstinence are strongly associated with psychological distress, depression, anxiety and low quality of life, in addition to underlying ill-health represented by CD4 cell counts and duration or severity of illness.
As proteasome function plays a prominent role in the UPR pathway ([26], [27], [28]), we measured the proteasomal activity in cells depleted or not of laforin and subjected to conditions of ER-stress (treatment with thapsigargin).
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