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After prolonged controlled mechanical ventilation (i.e., more than 72 hours), prolonged (i.e., 48 hours) NAVA improves diaphragm efficiency whereas prolonged PSV does not Over a prolonged observation period, patient-ventilator interactions were significantly different between NAVA and PSV.
However, specific effect of temperature variation during a prolonged observation period may be blunted by many factors that may interfere with the hemodynamic status of a critically ill patient.
Furthermore, attenuation of mnt1Δ only became evident after a prolonged observation period while mortality rates after 24 h were indistinguishable between mnt1Δ and its parental strain.
The production of hIFN-α was only followed for a time period of three months and a prolonged observation is needed to determine the duration of secretion of the transgene product after intraocular administration.
In the Swiss Cohort Study HCV coinfection was independently associated with a 21% reduction in the likelihood of increasing the CD4+ T-cell counts by at least 50 cells/µL and with an increased risk of progression to AIDS and to death among patients initiating HAART [5], and higher HCV RNA levels were associated with more CD4+ T-cell depletion in a prolonged observation (4 years) [6].
As an important concern for the late toxicity data, a prolonged observation period is required.
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The majority of adverse experiences were common childhood ailments and minor accidents to be expected in any population of this age range over a moderately prolonged observation period.
First, though extremely time- and resource-consuming, long-or longer-term large-animal models with a more prolonged observation period (that is, days) are needed and will probably yield valuable clues to the design of clinical studies.
Though the majority of patients have benign causes, uncertainty during the physician's initial assessment may result in unnecessary tests and prolonged observation before a definitive disposition decision can be made.
A meticulous history recording and prolonged observation during physical exam should be performed in all cases of trigeminal neuralgia to avoid underestimation of a possible "painful tic convulsif".
Blakemore and Campbell [ 14] found that after prolonged observation of a high-contrast sinusoidal grating, gratings of similar spatial frequency were harder to detect; more contrast was needed to see them at threshold.
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