Sentence examples for a prolonged dose from inspiring English sources

However, longer exposure times (>20 hours) produce a significant decrease in free cholesterol levels (Figure 2), suggesting that a prolonged dose of HPB-CD is necessary to effect clearance of stored intracellular lipids.

However, it may also be possible that a prolonged dose escalation period in the EVIDENCE study may have contributed to this observation.

This study treating children and young people with DIPG with a prolonged dose dense temozolomide regimen in addition to focal radiotherapy showed no overall survival benefit over radiotherapy alone [4].

The second episode of chemotherapy-induced leukopenia has led to a prolonged dose reduction (50percentt) of gemcitabine for three subsequent cycles.

36 Despite the rapid clearance, carfilzomib produced a prolonged dose-dependent inhibition of 20S proteasome in all tissues except the brain.

A prolonged dosing regime has been shown to be feasible and safe in a paediatric population [24].

A recently reported study in adults with recurrent high grade glioma, suggested a lower activity of this dose dense schedule compared to standard 5 days despite the strong theoretical rationale of using a prolonged dosing schedule [31].

Clinically, the cumulative dose effects on bone formation might contribute to osteonecrosis of the jaw in patients treated with a high-frequency dosing regimen [ 15] and to atypical fractures in patients with osteoporosis and a prolonged dosing regimen [ 11, 12, 16].

The benefit of this prolonged PAE value of tobramycin may allow for prolonged dose intervals without reduced efficacy and possibly a lower frequency of adverse events during K. pneumoniae therapy.

Little is known about the biological effects in humans after such a prolonged low dose exposure to these chemicals.

One of the hypotheses raised by the authors to explain these deceiving results is that the trabectedin dose intensity was insufficient due to prolonged dose delays.