Maximum plitidepsin concentrations were typically observed during or immediately before the end of infusion and then decreased in a multiexponential manner, with an initial rapid decline followed by a more prolonged distribution.
The NCPs demonstrated a targeted and prolonged distribution of microRNAs to metastatic liver tumors.
4. The World Metrology Organization proposed two definitions for drought: a) Prolonged absence or poor distribution of precipitation; and b) Period of abnormally dry weather sufficiently prolonged for the lack of precipitation to cause a serious hydrological imbalance.
The pollen tube path in a majority of plants has evolved from an extragynoecial compitum to an internalized one through syncarpy, which has offered greater advantages by providing favourable conditions and the necessary nutrition for a prolonged, lengthier and even distribution of tube growth inside the pistil (Labarca and Loewus 1973; Herrero and Dickinson 1979; Herrero and Hormaza 1996).
For example, lipophilic drugs in combination with the normal age-related changes to the patient's body composition (eg, the increased proportion of fat mass with loss of lean mass and decreased total body water) tend to result in an increased volume of distribution and a prolonged half-life, whereas water-soluble drugs tend to have a decreased volume of distribution.
The wide epidemic distribution suggests a prolonged period of disease transmission, rather than a single point source outbreak.
Studies from the 1940s suggest that quinacrine is associated with extensive tissue distribution and a prolonged pharmacologic half-life [ 3, 4].
This finding is reasonable because a distribution of the same amount of baits along a prolonged flight line produces a finer and more regular distribution on the ground.
After a single dose, plasma vosaroxin concentrations declined in a biphasic manner with a short initial distribution phase, followed by a prolonged elimination phase.
Three new BChE mutants (E364-532, E377-516, and E535) were predicted to have a more stable dimer structure with the desirable cross-subunit disulfide bond(s) and, therefore, a different distribution of the oligomeric forms and a prolonged biological half-life.
