The phrase "a prolonged change" is correct and usable in written English.
It can be used to describe a change that lasts for an extended period of time, often implying a significant or impactful transformation.
Example: "The organization underwent a prolonged change in its management structure, which affected all employees."
Alternatives: "an extended alteration" or "a lasting modification".
Here the change of calcium in time is emphasized to prevent a prolonged change of calcium concentration from dominating the change of synaptic efficacy.
Since the increase in Mmp13−/− callus bone volume observed by histomorphometry persisted through 8 weeks post-fracture, these results reflected a prolonged change in the bone volume of the mutant callus.
Hydrogen peroxide has a short half-life in cell culture medium (up to 20 minutes) [27], [28], [29], hence we conclude that a single, brief challenge with hydrogen peroxide is able to trigger a prolonged change in cell surface expression of HA-TPβ.
63 secreted proteins changed in abundance indicating a prolonged change in protein abundance compared to gene expression.
On the basis of this observation, we hypothesized that TCam-2 cells need to trigger rescue processes that let them survive after a prolonged change of gravity vector.
In order to avoid counting short-time fluctuations that do not correspond to a prolonged change of the toggle state, we a applied sliding-window average to the time series, using a window size of 1000 sec.
Previous comparisons between healthy and myalgic muscle during low-load repetitive work show that low-intensity activation evokes no prolonged change in single metabolite content in the myalgic muscle (Rosendal et al. 2004a, b).
Sudden or prolonged change in bowel habits.
In the TM populations staying in the microcosms for a prolonged time, changes are recorded in the phenotypic expression of plasmid genes (ampicillin resistance and the luminescence level) and chromosome genes (morphological and physiological traits).
"I'd decided to be a civil engineer after admiring some beautiful bridges," he said, but he found the vocation "too confining". His artistic career began with more traditional forms in the 1970s, but a prolonged illness changed his work radically.
Notably, both of them seem to measure the relative CF firing activity compared to its two temporal averages, giving the PC a chance to habituate to the prolonged changes in CF activity.
