The phrase "a prolonged application" is correct and usable in written English.
It can be used to describe a situation where something is applied or utilized over an extended period of time.
Example: "The study showed that a prolonged application of the treatment resulted in better patient outcomes."
Alternatives: "an extended use" or "a lengthy application".
The responses to the application of DA and DA agonists for a period of 1 min were similar to those observed after a prolonged application (3 min).
The effect due to a prolonged application of drain-source voltage (VDS) is small, though noticeable in terms of increasing the IDS only by 3% with continuous application of VDS for 3000 s.
In the first place, we do bring objects to pyrometric domains by prolonged heating that is to say, by a prolonged application of ordinary processes that cause the rise of temperature within the everyday domain.
"Although further analyses, including controlled sanitation experiments, are needed to substantiate these findings, our data allow careful speculation that a prolonged application of sanitation measures of kitchen sponges is not advisable".
It has been reported that a short Aβ fragment (Aβ25 35) first increased the expression level of a voltage-gated potassium channel subtype, but after a prolonged application, the expression level decreased [52].
However, wake-up time can be considerably delayed after a prolonged application of benzodiazepines and therefore, propofol has become a widely-used alternative worldwide [ 13].
Failure to remove tourniquets after needle insertion in to the vein of the patient and assurance of blood reach at the hub of the needle could also cause hemolysis as a result of prolonged application [ 25, 26].
Prolonged application of a low dose of a cytokine could exert functional activity, as has been published for IL-2 [63].
We found a biphasic action of Aβ42 at higher concentrations, which consists of an initial inhibition followed with prolonged application by the reappearance and then exaggeration of synchronicity.
Further, a study of Gamboa et al. [ 60] demonstrated reversed iTBS-effects after a prolonged, single application of 1200 instead of 600 stimuli.
Tolerance phenomena can occur with all opioids, but even with a prolonged remifentanil application (up to 10 days) the weighted mean infusion rate of remifentanil rose only slightly until day 3 and then was constant until day 10 [ 31].
