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QT prolongation is a risk factor for a form of ventricular tachycardia called torsade de pointes, which can lead to ventricular fibrillation and death.
For example, one regulatory definition of prolongation is a within-patient increase of 30 msec following initiation of a medication.
As a result, pimozide, a conventional antipsychotic with a high propensity for QTc prolongation, is contraindicated when treating patients with boceprevir and telaprevir.
Because i.v. As2O3 leads to a rapid surge of blood arsenic levels, arrhythmia related to QT prolongation is an important adverse effect.
Drug-induced QT prolongation is a potentially dangerous adverse effect of some medication combinations.
Drug-induced QT interval prolongation is a major concern in new drug candidate development.
We think that EIP prolongation is a feasible maneuver to optimize the consequences of mechanical ventilation in ARDS patients.
Introduction: Drug-induced QT prolongation is a major clinical risk factor for arrhythmia induction, particularly torsades de pointes.
In conclusion, our data indicate that EIP prolongation is a simple and feasible strategy to decrease dead space and PaCO2 levels.
QT interval prolongation is a risk factor for sudden cardiac death in healthy individuals [89] as well as those with ischemic heart disease [90] and chronic congestive heart failure [91], which are more common causes of death among centenarians than younger individuals [92].
QT prolongation is a common finding in the elderly.
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