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This syndrome is characterized by a prolongation in the depolarization time-course of cardiac myocyte action potentials, which can lead to fatal arrhythmias.
Clopidogrel produced a prolongation in R (4.4+/-1.4 4.4+/-1.4s. 5.4+/-1.7 min pret, p<0.001) that directly correlated with the change in platelet aggregation (r=0.65, p<0.0001).
We observed a prolongation in the lifespan of the treated mice that prompted us to develop a system of cannula implantation into the brain of prion-infected mice.
A prolongation in the lifespan of treated mice prompted us to develop a system of cannula implantation into the brain of prion-infected mice.
The study has 80% power to detect a prolongation in the prepatent period of approximately two days in immunized volunteers as compared with controls.
Electrocardiographic data from all trials demonstrated a prolongation in QTc (Fridericia corrected) interval associated with telavancin treatment.
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Previous smaller studies have not demonstrated such a prolongation, but in all studies, the control groups were not matched to the study group.
Administration of IgG from PMIF-immunized mice into naïve mice that were infected with PbAWT provided partial protection, with a delayed rise in parasitemia, a 30% reduction in peak parasitemia, a 30% prolongation in survival time in BALB/c mice (Supplementary Figure 9b), and a 30% reduction in lethality in C57/BL/6J mice (Supplementary Figure 9c).
In order to realize a significant prolongation in blood circulation, a combinatorial design, covalent attachment of polyethylene glycol (PEG) to polylactic acid (PLA) and physical adsorption of water-soluble chitosan (WSC) to particle surface, has been developed for surface modification of PLA NPs.
Electrophysiological remodeling resulted in a prolongation of APD, in agreement with clinical and experimental observations [ 1].
For radium-223, also a bone targeting agent, there was also a significant prolongation in time to first SSE in the overall trial population and also in the subgroup of patients receiving bisphosphonates [ 82].
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