In July 2012, there was a local recurrence, where a progressively hard nodule was felt in the left forearm at the site of the excised mass.
Amiga Computing also felt the high difficulty to be the "biggest problem": "I like a game to get progressively harder rather than getting virtually impossible after just four missions".
Teaching students that "it's fine not to get everything right", the scheme includes tests that get progressively harder within a time limit, preventing pupils from answering all of the questions.
That's because the long journey of, say, an avocado from Mexico gets progressively harder the closer it gets to the final consumer.
"But it helps decide what the next step should be". In a stress test, you walk on a treadmill that makes your heart work progressively harder.
This man's so far untreatable case of gonorrhoea may be a first, but it's an inevitable development in a wider crisis, where common infections have become progressively harder to treat.
This makes it progressively harder for users to leave, an economic principle known as lock-in.
The idea for the platform came to Nash, an app developer himself, after he found it progressively harder for his apps to gain traction.
These systems will not simply provide an advantage for natural gas; they will make it progressively harder and more expensive to transition to renewables.
The European commission has made it progressively harder to invoke, and last year the European parliament threw out a proposal to invoke Article 7 – or even to activate a warning mechanism.
Similar to our observations in Figure 2, Plk1 inhibition caused a dispersal of GFP-γ-tubulin from the centrosomes after NEBD and it became progressively harder to detect the GFP signal on the spindle poles.
