Two of the three patients with grade IV acute GVHD (SPN 3704 and 3783) required sirolimus discontinuation by day 9 post-HCT due to severe SOS and progressive altered mental status, respectively.
This is a progressive change, an unambiguously progressive change.
As a prime example, in Parkinson's disease, folding, post-translational modification and recycling of the synaptic protein α-synuclein are clearly altered, leading to a progressive accumulation of pathogenic protein species and the formation of intracellular inclusion bodies.
We applied the computational framework to elucidate the miRNA-mediated regulatory network in the Mir122a -/- mouse model, which has an altered transcriptome and progressive liver disease.
As the damage progresses, microglia undergo progressive changes, including altered expression of cell surface markers and inflammation-related genes, process retraction and the acquisition of an ameboid morphology, cell body migration, and increasing phagocytic ability [2].
A progressive, he has credentials for change.
After the fourth deprivation, a progressive ratio session was undertaken to determine if repeated deprivation cycles altered breakpoint values (Figure 4).
To say Henry Laufer, better known by his DJ/producer alter-ego, Shlohmo, has had a progressive and diverse career thus far would be an understatement.
A progressive is someone who makes progress".
Addiction is a progressive, chronic disease that literally changes the brain's reward, memory and motivation circuits, altering how it receives and processes information.
