Cancer appearance, development, and progression are characterized by a progressive accumulation of genetic mutations that abolish the natural constrains of cellular division in pluricellular organisms [ 1, 2].
Metallic tubes experiences a progressive accumulation of ovalisation, or ratchet, under cyclic inelastic bending.
One possibility is that, over time, aberrant DNA repair results in a progressive accumulation of oxidative damage to DNA.
Further examination of kidney and muscle pathologies revealed a progressive accumulation of CD45+ cells, first affecting the kidneys.
Depending on the kinematic hardening, the pipe may exhibit a ratcheting behaviour in the circumferential direction, which leads to a progressive accumulation of deformation.
The present paper presents a simple local criterion to indicate whether or not the pipe may exhibit a progressive accumulation of deformation.
Pompe disease is caused by the deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA) and results in a progressive accumulation of lysosomal glycogen.
CCl4-treated TG2 null mice showed a derangement of the hepatic lobular architecture and a progressive accumulation of extracellular matrix (ECM) components and inflammatory cells which were not observed in the liver of control animals.
The habitual use of high rates of N fertiliser and the frequency of dry years in the agrosystem studied generated a progressive accumulation of residual in the soil profile.
This difference can also be observed in regulatory regions and can be attributable to either a progressive accumulation of mutations due to errors in the transcription-coupled repair or an age-related decay of the mechanisms in charge of specifically repairing the exons33.
We demonstrate that sleep loss, but not sleep fragmentation, in healthy mice increases sensitivity to noxious stimuli (referred to as 'pain') without general sensory hyper-responsiveness. Moderate daily repeated sleep loss leads to a progressive accumulation of sleep debt and also to exaggerated pain responses, both of which are rescued after restoration of normal sleep.
