This project therefore involved a progression of yearly studies, each building upon the new knowledge gained from the results of the previous year's study.
DOI: http://dx.doi.org/10.7554/eLife.02755.002 Early neuronal development consists of a stereotypic progression of events involving neurite extension, axonal polarization and growth, dendritic arborization, and synaptic formation (Urbanska et al., 2008; Barnes and Polleux, 2009; Caceres et al., 2012).
The UPR is a defined progression of events involving only few ER transmembrane proteins: (I) activation of the kinase PERK; this phosphorylates eIF2a, which induces transcription factor ATF4 and blocks translation; (II) activation of IRE1, which triggers protein kinase JNK and produces transcription factor XBP1 by an unconventional splicing event; and (III) processing and activation of ATF6.
It can be hypothesized that this relation reflects a progression pattern involving clonal expansion of tumor cells that have acquired deletion of the BRCA2wt allele.
Newer approaches could involve integrative rather than reductionist approaches because the progression of OA involves an intricate interplay of transcription factors, extracellular matrix synthesis, assembly and degradation, all of which may be affected by the genetic background and environment.
The progression of labor involves a surge in stress hormones, including catecholamines and cortisol, in the infant to promote lung maturity for gas exchange, increase blood flow, activate the central nervous system and mobilize fuel [ 1, 2].
However, accumulating evidence supports an alternative model for the development and progression of HNSCC involving cancer stem cells (CSCs).
Progression of PVD involves extracellular matrix remodeling by elastases and matrix metalloproteinases (MMP), concomitant with proliferation of smooth muscle cells in a growth factor-enriched environment.
The initiation and progression of PC involves abnormal activation or inhibition of multiple intracellular signaling pathways.
Chest radiograph showed progression of consolidation, involving both left middle and lower zones.
It is well known that the development and progression of PCa involves the activation of oncogenic pathways.
