In many cases this involvement is indicative of a progressed stage of a primary malignant disease.
Patients included in this study suffered from cancer and were in a progressed stage of end of life care.
NEETs had higher symptom levels of depression, but not anxiety, and were more likely to be in a progressed stage of mental illness (Clinical stage 2).
In addition, the ubiquitinated motor neurons frequently show a flattened and eccentric nucleus, suggestive of a progressed stage of degeneration [ 29].
Collectively, the decrease of aggrecan levels in the RA patients compared to healthy individuals might be a result of the disease being at a progressed stage, where much of the cartilage had already been lost.
We detected G-CSF receptor and G-CSF upregulation in SOD1-tg mice that were at a progressed stage of disease (week 19) as an indication of possible relevance of the G-CSF system in this mouse model (>5-fold upregulation of the G-CSF receptor; Fig. 3C).
Furthermore, it appears that males with mental health concerns are at considerable risk of being NEET and that headspace appears to be capturing these men at a later age, in a more progressed stage of mental illness and experiencing greater social dysfunction when compared to females.
These data also indicate that caution must be taken in treating human SS with therapies targeting the ICAM-1/LFA-1 interaction, since it is likely that most patients are diagnosed and request treatment in a more progressed stage of the disease.
The problem is, Shane, that you've seen that textbook graphic too many times of an ape progressing stage by stage into an upright man.
As PDAC is generally diagnosed in a progressed tumour stage, only for 15% of the patients a curative intended resection is a therapeutic option.
Of note, by choosing a fairly advanced AE induction time, we sought to mimic a progressed disease stage that might have a high probability to be refractory to therapy.
