The phrase "a programming of alteration" is not commonly used in written English and may sound awkward.
It could be used in a technical or academic context where you are discussing a system or process that involves changes or modifications.
Example: "The software includes a programming of alteration that allows users to customize their experience."
Alternatives: "a process of modification" or "a system of change".
In order to determine whether this panel of four genes represented a program of epigenetic alterations important for the immortalization of mammary epithelial cells, we examined whether these genes were methylated in the immortalized, but non-tumorigenic 184-A1 and MCF-10A mammary cells, as well as in the MCF-7 and MDA-231 breast cancer cell lines.
It has blunted efforts to force adoption of the radical program of alteration drawn up at the 1960 Democratic national convention.
The possible mechanisms that explain the intergenerational effects on birth weight and linear growth are not mutually exclusives and include mechanical factors caused by reduced space for the fetus to grow, fetal programming of metabolic alterations, shared genetic characteristics, epigenetic effect, and sociocultural factors [ 8].
Loss of RB resulted in a dramatic evolution of gene expression as a result of alterations in epigenetic programming.
We hypothesized that maternal fish oil supplementation would prevent the programming of offspring cardiovascular alterations.
On the contrary, the accumulation and/or the aberrant distribution of fat mass reported in children and adults born SGA may reflect the long-term fetal programming of adipose tissue alterations, both in terms of quantity and functions [35], and may contribute to the increased risk of developing the metabolic syndrome later in life [36].
Among the genes methylated, we identified a panel of four genes, two of which (RASSF1A and SFRP1), were also methylated in other immortalized mammary cell lines, suggesting that programs of epigenetic alterations mark early steps in the transformation process.
The programming is understood as developmental adaptation of metabolism and physiology as a consequence of alterations in fetal nutrition [ 83].
