Taking that first step to committing to do something is scary and exciting and you never really know what you'll encounter along the way that can have profoundly positive influences in your life.
In particular, the President's Emergency Plan for AIDS Relief has had a profoundly positive effect, exemplifying greater goodwill and influence (soft power) that can be gained from addressing the compelling and influential humanitarian imperative of health in LMICs.
But if he was an unsparing critic he was also a profoundly positive one.
But, since its ad revenues are print-based, it's a profoundly positive virtue.
Europe can play a profoundly positive role in dealing with migration and refugees, if we can find the political will.
The American-brokered peace treaty to be signed in Algeria this week is therefore a profoundly positive development.
And I think it is a profoundly positive thing," Mr Obama said on Friday.
Thirdly, the knowledge that my story was making a positive impact on people's lives had a profoundly positive impact on my own mental wellbeing.
Proponents asserted that it had a profoundly positive impact on people's lives.
One way to counter this negative pull is with a profoundly positive act.
