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Even if all three had found it a profoundly negative experience, this would not have changed the overall finding of the acceptability of the study – the majority of patients were very positive about receiving gemcitabine at home and preferred to it hospital care.
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Climate change and global warming will have a profoundly negative impact on these reefs.
Mercedes later blamed Rosberg for the incident, which appeared to have a profoundly negative effect on his season.
"We believe the legislation would likely have a profoundly negative impact on the ongoing negotiations – emboldening Iranian hardliners".
Severe chronic stress can have a profoundly negative impact on the brain, affecting plasticity, neurogenesis, memory and mood.
He said: "A ban on letting agent fees is a draconian measure, and will have a profoundly negative impact on the rental market.
This results not only in devastating personal consequences for the individuals, but a profoundly negative impact on Canada's reputation as a rights-respecting nation".
Candidates up and down the ballot were forced to spend more time seeking donations, while political ads funded by outsiders gave a profoundly negative shine to many contests.
Being left out or ending up with poor positioning can have a profoundly negative impact.
Smoking had a profoundly negative effect on the amputation rate as did an amputation prior to the transplant.
The degradation of the load-bearing capacity of reinforced concrete beams due to corrosion has a profoundly negative impact on the structural safety and integrity of a structure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com