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"a profound transformation" is a correct and usable phrase in written English.
It can be used to describe a significant and fundamental change in something or someone. Example: The company underwent a profound transformation after hiring a new CEO, leading to increased profits and a more positive work culture.
Exact(60)
In the past half century, backgammon tournaments — like backgammon itself — have undergone a profound transformation.
President Maduro promises a "profound transformation" of the nation's prison system.
What we'll be left with is very likely a profound transformation in America's healthcare system.
Mr. Robinson had undergone a profound transformation from self-described outlaw to religious devotee.
Nevertheless, during the latter centuries of the Zhou, Chinese mythology began to undergo a profound transformation.
The survivor, named Oscar, was taken to Briarcliff and has undergone a profound transformation, Ms. Laukhuf said.
For all its importance to the country's economy, the $10 billion Swiss watch industry is going through a profound transformation.
"New Renaissance" may be a bit of hype, but a profound transformation lies ahead for the practice of history.
The ability to get things wrong without loss of life represents a profound transformation in the conduct of war.
The reality is that the euphoria of 1997 - when he was elected and when a profound transformation seemed at hand - is long gone.
In 2018, however, America's attitude toward immigrants seems to have undergone such a profound transformation that Arendt's "so-called last hope, maybe the only hope" looks unfounded.
More suggestions(15)
a profound conversion
a substantial transformation
a profound metamorphosis
a tremendous transformation
a significant transformation
a fundamental transformation
a thorough transformation
a profound reorganisation
a profound shift
a profound turnaround
a severe transformation
a thoroughgoing transformation
a root and branch transformation
a deepening transformation
a far reaching transformation
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com