The question of promoter specificity of AF-4 family members is a profound issue that is the subject of active investigation in multiple laboratories.
The vestiges of wondering who might want to read what I write, how I could possibly do my vast and profound subject justice, and who am I to write a book anyway, are still felt.
How ironic that the most sexually reticent lady of the three should write not only the best book, but the one that dares to explore most deeply the profound subject of amorphous gender.
In South Africa at the end of his travels, Naipaul returns to his oldest and most profound subject: the nature of power explored through the corruptions of history and race.
Essay collections are having a bit of a moment these days, and Robinson is a master of the form, turning her keen mind to such sweeping and profound subjects as what it means to be human, the nature of grace, and Christian theology.
One suspects hyperbole here, for Porter's attachment to real things in art was philosophically profound: subjects and themes were not chosen merely as vehicles for formal exploration but had personal associations, as Justin Spring, also the author of books on Wolf Kahn and Jackson Pollock, frequently shows in detail.
The impact of such factors is profound subjecting them to emotional distress, interference with their employment, or use tension-lessoning, oblivion-producing substances such as alcohol [ 9].
But it can certainly affect access, and has a profound influence on subject".
It seems to me that his animus derives much more from a profound antipathy towards the subject matter of this research than from a concern about the scientific methods used to investigate it.
In the half-century between 1890 and 1950, a variety of fields and disciplines, from musicology and literary studies to biology, psychology, genetics, and eugenics, expressed a profound interest in the subject of rhythm.
Although a profound knowledge of the subject one is trying to model in a GIS is indispensable, so is a thorough understanding of the implications of whatever operation one is performing in the GIS.
