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The phrase "a profound shift in" is correct and usable in written English.
It can be used to describe a significant change or transformation in a particular area or context.
Example: "The recent technological advancements have led to a profound shift in how we communicate with one another."
Alternatives: "a significant change in" or "a major transformation in".
Exact(60)
It demands a profound shift in mentality.
It is a profound shift in what delivers value".
Mr Reagan's presidency signalled a profound shift in American life.
It's a profound shift in her public image, crystallized in one of the video's funniest scenes.
This period coincided with what felt like a profound shift in internet mores.
Their tolerance represented a profound shift in the behavior of the colony as a whole.
Bamako-born photographer Racine Keita agrees that Sidibé's photographs captured a profound shift in Mali.
Even so Tuesday's announcement marks a profound shift in foreign policy orientation.
The prices also show a profound shift in wealth in the US.
The regional income statistics reflect a profound shift in the region's economy and lifestyles.
He added, however, that "there is a profound shift in corporate computing.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com